“This is the first large scale study to find statistically robust evidence that treatment with chloroquine or hydroxychloroquine does not benefit patients with Covid-19,” said Mehra.
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“Instead, our findings suggest it may be associated with an increased risk of serious heart problems and increased risk of death,a he warned.
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The study analysed data from nearly 15,000 patients with Covid-19, receiving a combination of any of the four drug regimens and 81,000 controls.
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Treatment with these medications among patients with COVID-19, either alone or in combination with macrolide antibiotics, was linked to an increased risk of serious heart rhythm complications in these patients.
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Researchers suggest these treatment regimens should not be used to treat COVID-19 outside of clinical trials until results from randomised clinical trials are available to confirm the safety and efficacy of these medications for COVID-19 patients.
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“Randomised clinical trials are essential to confirm any harms or benefits associated with these agents. In the meantime, we suggest these drugs should not be used as treatments for COVID-19 outside of clinical trials,” said Mehra.
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Chloroquine is an antimalarial drug and its analogue, hydroxychloroquine, is used to treat autoimmune diseases including lupus and arthritis.
Countries should “be prepared, be innovative, think of vaccines as an investment
